The journal presents the high-priority research and innovative activity at the National Research Nuclear University MEPhI. Articles published in the journal report the results of basic research in nuclear physics, physics of nanostructures and condensed matter, physics of high energy densities and extreme states of matter, optics and laser physics, plasma physics, radiophysics and electronics, nonlinear mathematical physics, mathematical modeling in natural sciences. These articles inform about last achievements in the development and application of nuclear technologies, nuclear physics monitoring technologies, space technologies, nanotechnologies, laser, plasma, and beam technologies, solid-state electronic technologies, biotechnologies, and information technologies.